“São ___, most populous city in the Southern Hemisphere” crossword clue

Reveal the answer to see why it works and where this clue has appeared before.PAULO is the answer to the New York Times crossword clue “São ___, most populous city in the Southern Hemisphere”. It was last seen in the puzzle of April 17, 2025, where it runs at 54 Across and fills 5 squares. It crosses 5 other entries in that grid — those are listed below and are the quickest way to confirm the letters you already have.