“Reason to take a painkiller” crossword clue

Reveal the answer to see why it works and where this clue has appeared before.ACHE is the answer to the New York Times crossword clue “Reason to take a painkiller”. It was last seen in the puzzle of February 25, 2026, where it runs at 34 Across and fills 4 squares. It crosses 4 other entries in that grid — those are listed below and are the quickest way to confirm the letters you already have.